RNA Recognition & Binding
How small molecules and biomolecular partners recognize structured RNAs.
Molecular simulation · RNA structure & dynamics
Computational RNA Science for Binding, Folding, and Force Fields
The Yildirim Lab uses computational chemistry, molecular simulations, and biophysical modeling to understand RNA recognition, structure, folding, and dynamics at atomic resolution.
Research at a Glance
How we study RNA.
Our work combines molecular modeling, simulation, and method development to investigate nucleic-acid systems with biological and therapeutic relevance.
Meet the research group →RNA Force Fields
Developing and testing molecular mechanics models for reliable RNA simulations.
Folding & Dynamics
Exploring conformational ensembles, internal loops, and RNA folding pathways.
Software & Tools
Open-source software, workflows, and computational resources for the lab community.
Featured Research
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Selected questions and current directions.
Molecular recognition
Small Molecule–RNA Binding
Computational studies of ligand recognition in structured and disease-relevant RNAs.
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Methods
RNA Force Fields
Improving transferable models that reproduce RNA structure, energetics, and dynamics.
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Dynamics
RNA Folding & Internal Loops
Connecting computational ensembles with experimental observables and structural behavior.
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